We also showed that upregulation of u-shaped was delayed until after lozenge activation, consistent with our previous results that showed u-shaped expression in the crystal cell lineage is dependent on both Serpent and Lozenge.
In the present study, we observed that Cd-MEC co-cultured SCd-MEC co-cultured-shaped expression in the SCd-MEC co-culturedCG-2, OCT-4, and WNT3.
A V-shaped expression of PCNA in both oocytes and somatic cells was observed in ovaries from 13.5 18.5 dpc and from 18.5 dpc to 5 dpp, which is closely correlated with the meiotic prophase I progression from pre-leptotene to pachytene and from pachytene to diplotene.
WNT signaling activation, which is considered a functional marker of CSCs (Vermeulen et al. 2010), showed a similar "U-shaped" expression pattern in SCs over 3 weeks of MEC co-culture [see Supplemental Material, Figure 1A (http://dx.doi.org/10.1289/ehp.1204987)].
A V-shaped expression pattern of PCNA in both oocytes and somatic cells was observed during the development of fetal and neonatal mouse ovaries, decreasing from 13.5 to 18.5 dpc and increasing from 18.5 dpc to 5 dpp.
Regarding the expression extensity in pancreatic cancer tissues, Wnt5a showed a bell-shaped expression pattern with a significant peak in well-differentiated carcinomas.
The bell-shaped expression pattern suggests that Wnt5a may play a distinct role in different cellular contexts.
In later stages an expansion of the endogenous horseshoe-shaped expression domain is also found (data not shown).
Furthermore, the U-shaped expression profile of MYC when plotted against SMNDC1 suggests that MYC has divergent roles in different tissues.
In Monolith, van Linden Tol created an explosion in which black powder left two monolith-shaped expressions on the surface of pages from The Bible.
Although it is also possible that bell-shaped or inverse bell-shaped expression systems are caused by feedback regulatory loops, which may involve genes acting further downstream, 49 primary Oct3/4 target genes that fall into this category are most likely regulated in a similar manner as Zfp42/Rex1.
