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It is possible to identify the cell morphology changes between the beginning (Figure 3a) and the end of the measurement (Figure 3b), with a slight change in shape, reorganisation of small lipid structure, or movements of nucleoli.
These include a loss of epithelial-like polygonal morphology, basal cell polarity and adhesive contacts, development of a fibroblast-like shape, reorganisation of cytoskeleton filaments, increased cell motility and induction of proteases for ECM degradation requisite for migration and invasion.
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In corneal epithelial cells, bFGF induces a change in cell morphology from a polygonal to fibroblastic shape and a reorganisation of the actin cytoskeleton through PI3K (Lee and Kay, 2003).
After winning over many at first, he found himself under attack this summer when senior people began leaving in a huff, or were fired, as the reorganisation took shape.
This appears to be linked to a particular change in cell shape and cytoskeletal (actin) reorganisation, as treatment of these cells with cytochalasin D (Cyt D), but not with latrunculin B, recapitulates and potentiates TF upregulation.
Ward, N. S. & Frackowiak, R. S. The functional anatomy of cerebral reorganisation after focal brain injury.
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Rac1 is also an upstream regulator of actin reorganisation and adhesive properties associated with cellular shape and motility (Nobes and Hall, 1999; Ridley et al, 2001).
Cellular differentiation is associated with ECM remodelling, regulation of matrix metalloproteinases (MMPs), reorganisation of the actin cytoskeleton, and changes in cell shape.
Reduced oxygenation causes dynamic reorganisation of the actin cytoskeleton resulting in changes of cell contractility, shape and motility [ 27] thereby providing important information on cell state and activation.
Reorganised school networks Teachers have had different experiences from the reorganisation of the school network.
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