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For example, most guideline studies only examine three treatment doses, which is not sufficient to make a conclusive judgment about the shape of the dose response curve.
We also categorized all PCB measures into tertiles, based on the rank order, to explore the shape of the dose response relationships.
This smoothed curve, which does not rely on assumptions about the shape of the dose response, is similar to the linear fit over the low dose range.
Although the data do not allow precise characterisation of the shape of the dose response, the data are consistent with linearity over the low dose range.
The shape of the dose response curve for Bcl2-acta differs from that of both wt Bcl-2, and BclX-acta.
While this model may be appropriate for risk predictions at high doses, the shape of the dose response curve at low doses is not well understood.
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Uncertainties that could compromise the TEF concept were also reviewed, including nonadditive interactions, differences in shape of the dose-response curve, and species responsiveness.
The shape of the dose -response curve was similar to the one earlier foundose -responsepes of environmental noises.
However, this mechanism cannot explain why this parasitoid responds differentially to blend quantity in a dilution series of the 4 compounds using triethyl citrate (TEC), as can be inferred from the parabolic shape of the dose-response relation (Figure 5c).
However, the exact shape of the dose-response curve remains unclear.
There are two issues with applying Lutz's reasoning to the shape of the dose-response curve.
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