More recently, random regression approaches have been proposed, which allow a model to be fitted to the yield data in which the data itself specifies the shape of the fitted model, rather than fitting to a pre-specified mathematical function [ 7, 8].
We agree that there is considerable uncertainty in the shape of the fitted curves reflecting the uncertainty in gametocyte density and the variability seen in mosquito feeding assays.
Apparently, Ed Sheeran's Shape of You fits the bill perfectly, while the "low key" sound of New Zealand band Yumi Zouma "is simply too pale".
This indicates that the shape of the fitted curve is concave down with the maximum at x = −d/2c, and that the Sq amplitude tends to saturate for a high solar F10.7 index.
However, the shape of the fitted curve is often hardly affected in such cases, as either parameter g is close to zero or close to unity, or (k_1) and (k_2) converge to practically equal values.
Estimates of the shape parameter β in the periodic model varied between 2.5 and 124.8, showing that the shape of the fitted curve varies widely.
For both models, likelihood ratio tests were used to test for between-subgroup heterogeneity in both the location and shape of lines fitted within glycemia arms.
Compared to the former approach, the latter one has several advantages: no need for the selection of cut-points to categorize exposure, which can influence the shape of a fitted dose-response curve; no power loss; and ease of comparisons across studies [ 20, 23].
The results indicate a substantial rise in mortality hazards for patients with more than one co-morbid condition – the Charlson index includes heart disease, thus all subjects in this study have one 'co-morbidity', but the logarithmic shape of the fitted line implies that the impact of additional co-morbid conditions lessens with the presence of more co-morbid conditions.
