Understanding how social determinants of health interact to ultimately shape a population's pattern of disease is a daunting task, full of methodological complexity and theoretical uncertainty.
This notion is grounded in the understanding that societies shape patterns of disease and that these patterns change over time in response to multiple factors [ 38, 39].
Americans are stunned by the artistic feel, the vivid color and amazing shape of 'the disease.'" In other words, the beauty of the PHSCologram broke through the fear of the disease, and paved the way for discussions on an otherwise culturally forbidden subject.
If the shape of the disease hazard is known to be different from that of a particular distribution, then the data should not be analysed with this parametric model.
The shape of the disease-associated allele frequency distribution did not resemble either null expectation, suggesting that additional factors were involved.
It is important to note that evolution has shaped the burden of disease in the modern world in which we practice and educate for public health.
Chronic forms of morbidity, including mental disorders and hypertension, play a central role in shaping the burden of disease in the developing world.
The importance of seasonality in shaping temporal patterns of disease risk and livelihood impacts, and its relative neglect by researchers, was highlighted by Chambers [ 1, 2].
This marker is therefore of little use for predicting pathogenicity of circulating strains, as it seems to be the expression of the gene, rather than any particular mutation, that is important in shaping the outcome of disease.
The results presented here suggest that secondary transmission of leptospirosis via human travel and migration across national borders is re-shaping the landscape of disease incidence and prevalence worldwide.
