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SYD-2 (liprin-alpha) was previously shown to regulate the size and the shape of active zones.
Experimental results indicate that the shape of active pressure distribution diagram behind a cantilever retaining wall is non-linear and varies depending on the wall flexibility and characteristics of deformable layer.
The distribution and shape of active units in skeletal muscle relies on the mitochondrial organization, especially on the presence of thin and thick columns, as described in [12].
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Shape tailoring of active materials could alter the performance of supercapacitors.
This might be due to the fact that this crystal structure carries two mutations within its active site, appreciably changing the shape of the active site.
The active site residues were not restored, and the shape of the active site is rather different.
Q506P and Q510E mutations do not alter the shape of the active site pocket but appear to decrease the positive electrostatic potential within the active site.
Also, the C-terminal tail is not α-helical, as is the case for the bacterial NATs, but is instead a coil that reaches around and associates with the active site cleft, thereby playing a key role in defining the size and shape of the active site pocket.
These findings imply that mutation or activation processes do not significantly alter the global shape of the active site, but affect the spatial arrangement of catalytic Cys163, in agreement with a previous report showing that activation of caspase-7 leads to rearrangement of a loop containing the catalytic cysteine [ 24].
Because the C-terminal tail has an important role in defining the size and shape of the active site cavity, a significant amino acid change at this position is likely to alter active site access and substrate selectivity, which is consistent with the substrate-dependent activity changes observed experimentally for the G286 variant.
The complexes exhibit the desired shape of their active surfaces, as proved by X-ray analysis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com