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Small Angle X-ray Scattering (SAXS) is a powerful tool in the study of biological macromolecules providing information about the shape, conformation, assembly and folding states in solution.
Compared to conventional molecular design for organic NLO materials, the concept of using nanoscale architectural control to tailor the size, shape, conformation, and functionality of NLO chromophores and macromolecules provides a great opportunity for simultaneous optimization of macroscopic electro-optic activity, thermal stability, and optical loss.
These peptides are restricted to triangular prism shape conformation due to the 'PxxP' motif [17], [18].
For example, the two-dimensional Y shape conformation of cocaine aptamers (CBA45 and CBA51) showed a smaller steric hindrance than the three-dimensional G-quartette structure of thrombin aptamers (TBA30 and TBA44), resulting in their much higher probe densities.
Designing drugs for epilepsy requires techniques for determining the geometry, conformation (shape) and electronic properties of both small molecules and macromolecules.
Arrowheads show hypothetical nuclease cleavage sites relative to a ribosome in a non-rotated or rotated conformation (shape is for illustration only).
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The L-shape conformation of this compound in the active site of FXa was recognized as an important factor in displaying its FXa inhibitory activity.
These scaffolds are rigid and are allowed to adopt an L-shape conformation which was estimated as the active conformation based on a docking study of YM-60828 with FXa.
The quantitative nanomechanical measurements in conjunction with nonlinear mechanics modeling and molecular dynamics simulations reveal that a reversible out-of-plane buckling delamination of graphene occurs in its early-stage folding process, which enables graphene to deform into a stable self-folded z-shape conformation.
The end capping groups not only extend the molecular conjugation leading to a red shifted emission, but have a propeller shaped conformation.
Proteins that recognize the L-shape conformation of GalCer-HFA can totally ignore GalCer-NFA, as perfectly demonstrated for the HIV-1 surface envelope glycoprotein gp120 [28].
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