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Previous studies reported that the migration of epithelial cells involves alteration of enterocyte shape and phenotype, including extension of the plasma membrane in the direction of cell migration and assembly of new focal contacts at the leading edge [19], [40], [41].
Microglia are activated after ischemic stroke, changing shape and phenotype, similar to macrophages in systemic inflammation.
Accordingly, a meaningful example of nonequilibrium reaction influenced by gravity in living systems is represented by microtubules and microfilaments dynamics, as well as by shape and phenotype differentiation [ 6, 7].
This is particularly important as cells contained within a tumour are highly heterogeneous for size, shape and phenotype (Fig. 1C) and exclusion of any cells based on any of these parameters might result in loss of cells of interest, a consideration that becomes most prominent when dealing with extremely rare cells within a tissue such as CTCs within the blood.
To test whether differences appeared in the leaf shape and phenotype between wild-type and CsHMA3 transgenic lines at the vegetative and reproductive stages (Additional file 5: Figure S5), the length, width, angle, number of leaves, and stem length of plants were measured.
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These collected data suggest that the different shapes and phenotypes of fibroblasts seen in obstructed kidneys are different functional stages of one cell type.
Similarly, cells with aberrant cytoskeletal rearrangements lose the spherical shape, and this phenotype often results because of the increased proliferation and loss of the epithelial polarized organization.
Moreover, even if one takes the arguably simplistic approach of simply defining every human as male versus female, there are numerous robust and reliable sex differences in the size, shape and neurochemical phenotype of specific brain regions in boys versus girls and men versus women.
This function is separate from the first two functional aspects derived from leaf shape and trichome phenotypes, as sub mutants do not share these phenotypic aspects [ 2].
In complex organisms, different tissues express different genes, which ultimately shape the function and phenotype of each tissue.
Despite the critical role of CNVs in shaping genotypes and phenotypes, the majority of the identified CNVs have not yet been finely resolved to the nucleotide level.
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CEO of Professional Science Editing for Scientists @ prosciediting.com