Zebrafish and medaka mutants with perturbations in the EDA pathway display severe skeletal abnormalities, such as loss of fins and scales, missing and abnormally shaped teeth, and abnormal craniofacial morphology (Harris et al., 2008; Iida et al., 2014).
Genetic screens have identified a class of mutants known as DISTORTED mutants because of their significant actin-related cytoskeletal growth-associated phenotypic defects and overall distorted cell shape patterning and abnormal polarized growth (trichome, epidermis, cell-cell communication) [ 2, 4- 6].
After 7 days in co-culture, chondrocytes in both groups were in normal shape and no abnormal diploid cell was observed.
The criteria of the occurrence of particular contact wear shapes (normal and abnormal) were defined on the basis of the simulated stress distribution analysis.
A direct comparison of the shape and contour of abnormal regions depicted by T2-weighted-MRI with the shape and contour of the area-at-risk as determined by anatomic pathology in a canine model of acute MI.
Higher magnification images show that dilated vessels typically lacked pericyte support, had thinned capillary walls and abnormal shape (arrowheads, Figure 4B, d-f and 4D, j-l).
The following conditions are regarded as postural defects: abnormal shape of the physiological spinal curvatures, asymmetrical positioning of the shoulder or pelvic girdle, disturbance of the knee joint axis and abnormal shape of the foot arches.
We well understand that malaria infection and abnormal shape of erythrocytes are major critical diseases of human erythrocytes.
Use of a custom femoral stem gives a reliable fixation and promising medium-term clinical results in femurs of normal and abnormal shape and dimension.
The presence or absence of four primary findings of ACL tears, i.e., nonvisualization, discontinuity, abnormal signal intensity, and abnormal shape of the ACL, and five secondary findings, i.e., anterior translation of the tibia relative to the femur (≥7 mm), posterior cruciate ligament angle (<105°), bone contusion, Segond fracture, and the deep sulcus sign, were determined.
