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The substrate binding pocket is shallow, dynamic, and solvent-exposed, as was discovered with HCV protease.
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Using the assumed-mode method, the finite degrees of freedom dynamical system is derived to analyze the shallow shell dynamic instability.
Past inputs have been thoroughly mixed throughout this shallow and dynamic estuary.
Being both shallow and dynamic, this active site is particularly challenging to inhibit.
An alternative approach that could potentially overcome limitations inherent to targeting the shallow and dynamic active site is identifying small molecules that prevent dimerization, and thus inhibit one or more of the HHV proteases.
Estuaries and shallow bays are dynamic environments, influenced by tidal variations and inflow of freshwater from rivers and channels.
Shallow breathing during dynamic volume CT scanning reduces the overall demand for motion correction and thus may be beneficial in perfusion imaging of the pancreas.
It consists of a shallow shell (the dynamic absorbing shell), under the same boundary condition and with the same shape as those of the main shell, with connecting springs and dampers in the vertical direction between the main and dynamic absorbing shells.
Because these proteases have thus far been recalcitrant to noncovalent active site inhibition, likely because of their shallow and conformationally dynamic substrate binding site, we pursued allosteric inhibitors.
The rapid shallow breathing index (SBI), dynamic compliance (Cdyn), minute ventilation (MV) and spontaneous tidal volume (VT spont) were obtained from the ventilator (Servo i, Maquet).
We provide an adaptive strategy for solving shallow water equations with dynamic grid adaptation including a sparse representation of the bottom topography.
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