Sentence examples for shallow dose response from inspiring English sources

Although a definitive plateau of binding was not quite achieved, the change of slope at high numbers of cells indicated that only a very shallow dose response occurred at the high end of the curve.

The cell lines we tested had IC50s to bafilomycin A that ranged from 10 nM to greater than 10 µM and we chose the moderately sensitive cell line HeLa (IC50 = 150 nM) for our experiments because its relatively shallow dose response made for more uniform growth inhibition experiments, suggesting that the gene expression experiments would also be more reproducible.

The risks for renovascular effects in prior trials of the etoricoxib clinical development program were low with a shallow dose response and were generally similar to those found with naproxen or ibuprofen [ 16].

Importantly, these shallow dose responses provide evidence against a non-specific mechanism of inhibition involving colloidal CLR01 aggregates, as aggregating inhibitors tend to exhibit steep dose response curves (Shoichet, 2006).

This well-controlled, statistically powerful study in middle-aged men demonstrated that vardenafil and sildenafil produced no increase of absolute QT and only similar, small increases of the QTc interval, with a shallow dose-response curve.

This relatively shallow dose-response relationship between input virus dose and ensuing vector-specific NAb titers suggests that these NAb responses are fully generated by relatively low amounts (containing ≤104 PFU) of input viral inocula.

Recently, Fallahi-Sichani et al. showed that for the relative viability of cancer cells treated with phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) pathway inhibitors, a shallow dose-response curve was associated with cell-to-cell variability in the degree of signal inhibition.

BPA consistently increased transcription of the mcERR between 1.1-fold (at 10−6 M) and up to 2-fold (at 10−4 M) in repeated assays, resulting in a shallow dose-response curve between 10−8 and 10−4 M (Fig. 3A).

Dose response demonstrated very shallow QTc relations for study drugs.

However, the slope of the dose response curves are rather shallow so we would not predict a dramatically increased benefit.

Another thing: pharmaceutical researchers are often looking at something they call "the dose response".