Sentence examples for shallow dose from inspiring English sources
Although a definitive plateau of binding was not quite achieved, the change of slope at high numbers of cells indicated that only a very shallow dose response occurred at the high end of the curve.
The cell lines we tested had IC50s to bafilomycin A that ranged from 10 nM to greater than 10 µM and we chose the moderately sensitive cell line HeLa (IC50 = 150 nM) for our experiments because its relatively shallow dose response made for more uniform growth inhibition experiments, suggesting that the gene expression experiments would also be more reproducible.
Importantly, these shallow dose responses provide evidence against a non-specific mechanism of inhibition involving colloidal CLR01 aggregates, as aggregating inhibitors tend to exhibit steep dose response curves (Shoichet, 2006).
The risks for renovascular effects in prior trials of the etoricoxib clinical development program were low with a shallow dose response and were generally similar to those found with naproxen or ibuprofen [ 16].
This well-controlled, statistically powerful study in middle-aged men demonstrated that vardenafil and sildenafil produced no increase of absolute QT and only similar, small increases of the QTc interval, with a shallow dose-response curve.
This relatively shallow dose-response relationship between input virus dose and ensuing vector-specific NAb titers suggests that these NAb responses are fully generated by relatively low amounts (containing ≤104 PFU) of input viral inocula.
In contrast, CYC3 demonstrated a shallow dose-dependent increase in toxicity.
Recently, Fallahi-Sichani et al. showed that for the relative viability of cancer cells treated with phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) pathway inhibitors, a shallow dose-response curve was associated with cell-to-cell variability in the degree of signal inhibition.
BPA consistently increased transcription of the mcERR between 1.1-fold (at 10−6 M) and up to 2-fold (at 10−4 M) in repeated assays, resulting in a shallow dose-response curve between 10−8 and 10−4 M (Fig. 3A).
The simulation results indicate that the method can predict the shallow and deep dose in various radiation fields with relative errors less than 20%.
CT data were acquired in shallow breathing with dose modulation between 15 and 80 mA, 120 kVp and a pitch of 0.984 1, reconstructed to images of 0.98-mm transverse pixel size and 3.75-mm slice thickness.
