FTND was established as gold standard and the following statistics, summarizing the diagnostic accuracy of the HSI, were obtained, and also stratified by sex: sensitivity, specificity, accuracy and positive and negative predictive values.
Epidemiological studies have reported differences in prevalence rates between males and females in the US [ 8, 15] and Iran [ 2, 11] bringing to the fore the sex sensitivity of both algorithms.
Using similar analysis, we set the optimal cut-off for detecting insulin resistance state at 105 cm for waist circumference in both sexes (sensitivity and specificity of 78% and 62% respectively).
Overall, HKC(m) were nearly as sensitive as PKC towards OTA, followed by RPTC, LLC-PK1 and HKC f), thus suggesting a sex specific sensitivity in humans towards OTA induced cytotoxicity.
Their final effect on neuronal function depends on many factors, including the hormone type, its active metabolite (or their combination), treatment duration, dose, brain region, sex, hormone receptor sensitivity, and local steroid-hormone production in the brain.
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For sex (male) sensitivity ranged from 0.37 to 0.78, while specificity ranged from 0.46 to 0.57 (table 3).
In these models the trait was the dependent variable whereas age, sex, insulin sensitivity and genotype were the independent variables.
Therefore, this environmental factor may act epigenetically in multiple brain regions to alter sex specific sensitivity to stress, although this hypothesis has yet to be tested.
In forward stepwise linear regression analyses including palmitoleate at baseline, age, sex, insulin sensitivity at baseline, and body fat at baseline and at follow-up, high palmitoleate levels predicted a larger increase in insulin sensitivity (P = 0.02, supplemental Table 3).
Pearson correlation, and univariate and multivariable linear regression models were used to examine the associations between eGFR determined by Bouvet equation and the natural log of ACR (log transformed for these analyses because of skewed distribution) and VO2peak, unadjusted and adjusted for Tanner stage, sex, insulin sensitivity, HbA1c level, systolic blood pressure (SBP), and LDL-C level.
