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Differently from the proportion of utilitarian responses, no evidence was found of sex modulation (interactive terms involving "Sex" were consistently non-significant; Table 2).
The candidacies of Igfbp5 and Igfbp2 as tumor suppressors also are consistent with the observed sex modulation of lung tumor multiplicity phenotype in the backcross population and with the significant interaction between the chromosomal region, where these genes map, and sex status in the control of lung tumor multiplicity.
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Very few studies have examined sex modulations of brain anatomical differences between individuals with ASD and typically developing (TD) individuals, especially in children.
Evidence of sex chromosome modulation of autosomal gene expression and downstream phenotypes is rapidly accumulating.
A much wider survey of ATF4-responsive mRNAs would be needed to develop hypotheses about patterns of sex-specific modulation of responses to acarbose that might contribute to the sex-specificity of the lifespan results.
Therefore, sex-specific modulation of CYP isoforms occurs following administration of EGCG and ECG in Swiss Webster mice.
In a mouse model, X chromosome dosage has been found to be at least as important as SRY for sex-dependent modulation of general gene expression.
Thus, lipid-derived hormones play an important (and perhaps conserved) role in the rapid sex-specific modulation of behavior in a broad array of animal species.
Sex-specific immune modulation is likely mediated by sex hormones through activation of their specific receptors.
As both oestrogen and testosterone have roles in modulating cell behaviour in aggressive fibromatosis, it is possible that sex steroid hormone modulation can be used to treat this tumour type.
The present data provide important new insights into the role of sex hormones in modulation of Th2 immunity.
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