Hence, detecting new aspects of prior "no signals" and of known causal associations, e.g. increased frequency, increased severity, greater specificity for selected patient populations or "striking" information about causality in new ICSRs, requires methods to bring SDRs to the attention of safety experts again.
Objectives: For acutely ill children living in less than optimal environments, mothers and pediatricians may have a heightened perception of illness severity, a lower specificity of clinical judgments, and a tendency to over-utilize resources.
This dose-dependent phenotypic severity indicates the specificity of pnpla6 knockdown.
Possible reasons for the contradictory reports are variation in disease severity, duration, tissue specificity or other experimental conditions [ 16].
These three present an outstanding experimental system because, although they are highly similar at the DNA sequence level, they vary in critical aspects of bacterial pathogenesis, including host specificity, severity of diseases, and duration of infections (acute versus chronic) [ 2].
Previous studies reported that genomic alteration or variability of viral population during infection could affect the organ-specificity, severity and immunological escape [ 37, 39, 41].
The analysis of the data shows that, controlling for APRDRG and severity, the geriatric specificities have important and complementary explanatory power on length of stay and intensity of nursing, rehabilitation and physician care.
The other recorded parameters have varying clinical specificity and severity, from mild to severe, but typically have little clinical impact, and may be very transient.
Together these data demonstrate that the surface phenotype of WNV memory cells vary with disease severity, age, and epitope specificity (Figure 5B).
Our data show that disease severity, age, and epitope specificity are associated with changes in memory T cell phenotype and frequency.
