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Recommendations of the Citizen's Council of the National Institute for Health and Clinical Excellence in the United Kingdom reflect some consensus among council members that ultra-orphan drugs (prevalence <0.18 per 10 000 population) be considered for special funding on the basis of severity, possibility for improvements in health, and life threatening disease.
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This new index simultaneously reflects the damage severity and possibility of damage at each structural component.
Then the numeric risk matrix is used to determine risk value of each step by considering severity and possibility.
Unmeasured differences in symptom severity are another possibility.
An important difference revealed by stratified analysis was that as severity increased, the possibility of retaining patients decreased.
The significant interaction between GHR isoforms and GHD severity raises the possibility that genotype and GH level could influence the total number of GHRs expressed on a cell and/or efficiency of GH signaling and/or alter the activity in cellular pathways related to GH responsiveness.
In the present article, we examine severe seizure phenotypes and explore the possibility that severity may be modulated by genetics.
Secondly, inherent hazards of oil storage tank zones are quantitatively evaluated by the major hazards method (flammable, explosive and toxic), which conducted on the possibility and severity of accidents.
Then, an adaptive folding index was proposed to measure the possibility and severity of folding defect based on the mechanism that there exists a local increase of strain rate when a folding tends to appear.
We defined the diagnosis such that all included patients had information on the pneumonia severity index, minimizing the possibility of non-pneumonia cases being included in the cohort.
Results are indicated by four different shades of red, corresponding to different PCT ranges, indicating the possibility and severity of sepsis [ 111].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com