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The severity of weakness and variability in reflex abnormality were noted.
Delayed sitting may be predictive of the severity of weakness indicating a higher risk for scoliosis.
Additionally, the persistence and higher severity of weakness at ICU discharge further increased the risk of death within the first year [ 11].
Upon recovery, the chance of walking unaided after few months can be calculated on the basis of the age of the patient, the presence of diarrhea, and severity of weakness in the first weeks.
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In summary, we found that mechanically ventilated MICU patients have severe diaphragm weakness, that the clinicians caring for these patients greatly underestimate the severity of diaphragm weakness present, and that infections are a major risk factor for the development of diaphragm weakness in this population.
The combination of neurophysiological testing with neuromuscular histology could therefore help in the precise identification of the type and severity of neuromuscular weakness, and may lead to a better understanding of the causes and consequences of neuromuscular weakness [ 5].
Despite considerable evidence that the deficit in intellectual function in DMD has a significant genetic component a simple relationship between the degree of cognitive impairment and the severity of muscle weakness has not been identified, suggesting that these interrelated phenotypes are under a degree of tissue specific control.
17 The severity of muscular weakness was scored at the level of arms (range from 1 to 6) and legs (range from 1 to 10).
The assessment of muscular strength and endurance provides information about the severity of muscle weakness and is the basis for the planning of specific exercise programs for each patient.
Because of the lack of sensitivity of clinical examination in such patients, combined electromyographic diagnosis and neuromuscular abnormalities on histology could help to identify the type and severity of neuromuscular weakness, and the functional prognosis.
Finally, to determine whether clinicians were cognizant of the severity of diaphragm weakness present in their patients, we asked the attending MICU physicians to estimate diaphragm strength and compared these estimates with objectively determined measurements.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com