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Future well designed trials are needed to evaluate quality of life and duration of side effects in addition to survival and severity of toxicities in this group of patients.
An additional 20% of that score reflects the number and severity of toxicities, or unwanted side effects, seen in clinical trials.
Substantial new or increased severity of toxicities was not reported during re-challenge.
Secondary measures included the disease control rate (ORR + stable disease), time to progression, and frequency and severity of toxicities.
The frequencies and severity of toxicities experienced with platin plus gemcitabine or pemetrexed regimens appear to be comparable to those found in the literature.
Safety evaluation was based on the frequency and severity of toxicities, graded according to the Common Terminology Criteria for Adverse Events (AE) [ 31].
Similar(47)
The toxicokinetic study revealed that the severity of toxicity was linear with the level of systemic exposure.
Due to decrease in severity of toxicity following phytoremediation by the macrophytes the total lipid (Table 3) and cholesterol concentrations (Table 3) increased significantly in comparison to the raw effluent exposed tissues.
In practice, clinicians must determine optimal dosage for each patient based on this fine line between benefit (killing cancer cells) and risk (severity of toxicity).
This would reduce the severity of toxicity due to leaf absorption.
The severity of toxicity related to concurrent chemoradiation was graded according to common toxicity criteria (CTC).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com