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Introduction: Differential expression of specific genes has been associated with postoperative brain injury and individual variation in the severity of the host response following cardiac surgery 1,2.
The clinical impact of ESBL-PE pneumonia was assessed from the rate of inappropriate empiric therapy, the severity of the host response, mortality rate and length of stay.
The severity of the host inflammatory response is highly related to the development of multiple organ dysfunction syndrome and is frequently seen in patients with sepsis.
Determining prognosis, namely mortality risk that is secondary to the severity of the host response to infection, is another important avenue of research pertaining to HRV analysis and infection.
Sepsis, severe sepsis and septic shock were defined 15 years ago as a continuum of increasing severity of the host response to the pathogen [ 3] closely related to predisposition, organ failure and systemic response, and to the microorganism and site of infection [ 7].
Which of these outcomes occurs after UPEC infection in C3H/HeN mice is determined within the first 24 h post-inoculation (hpi) and depends on the severity of the host's acute inflammatory response (Hannan et al., 2010).
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These authors observed that the outcome was influenced by the severity of the underlying host conditions, particularly with patients requiring mechanical ventilation [ 26].
Existing in vivo models of apoptosis include the induction of hepatocytic cell death by systemic administration of drugs, or the treatment of sensitive tumor xenograft models with chemo- or radiotherapy, but these suffer from both the severity of the procedure to the host animal, as well as the inherent variability of apoptotic response to stimuli.
A further and indirect mechanism may be the effect of glucocorticoids on the severity of, or host response to, infection, perhaps reflecting the consequences of prolonged adrenal suppression.
Fourteen days after receiving parental spleen cells, the F1-tumour-bearing mice were killed and their spleen ratios and indices were determined as an index of the severity of the graft-versus-host reaction (GvHR) induced.
Consequently, testing for a relationship between host performance and ascites, or any disease reducing host performance, is challenging because the incidence of infected animals and the severity of host performance reduction can influence the sign of the correlation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com