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Differences in the composition of particles and medication use or disease severity of study subjects may explain some inconsistencies between previous studies on HRV.
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The potential benefits of MEDI-528 observed in both studies should be interpreted with caution as these studies were also limited by the mild disease severity of the study population.
However, the majority of cytokine data found in this study would suggest that systemic cytokines are not good biomarkers for the severity of the study.
However, the differences in the results of these studies may be due to differences in race, age, and disease severity of the study population.
Sepsis severity of the study group was graded as follows: sepsis (n = 5), severe sepsis (n = 2) and septic shock (n = 28).
The NDS, a scale of 0 10, was used to stratify the neuropathic severity of the study participants into none (0 2), mild (3 5), moderate (6 8), and severe (9 and 10), as described elsewhere (21).
This is most likely due to the difference in migraine severity of the study populations.
Given the severity of our study, we employed a maximally diligent observation of all mice to minimize suffering within the frames of the experimental design.
†indicates Kellgren and Lawrence disease severity of the study limb.
More information regarding the demographic characteristics and disease severity of the study population has been published elsewhere [ 27, 28].
Hence, due to the high severity of our study patients, other factors might have exerted a crucial role affecting organ functions.
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