As a result of uncertainties of a correlation between incidence rates and severity of side effects with the effectiveness of palliative chemotherapy in colorectal cancer, particularly as it concerns the novel more effective combination regimens, the present study was performed.
Third, single items do not capture the complexity of treatment preferences, which are based on careful evaluation of the treatments' attributes such as effectiveness, severity of side effects, and convenience of implementing the treatment in daily life [ 21– 23].
Subgroups were planned a priori for age, gender, socioeconomic status, type of illness (mild or severe), size of absolute effect and severity of side effects.
Differences between groups were seen in the severity of side effects with a tendency for less severe effects in the NT group (table 4).
The ultimate goal of drug combination is to obtain effective analgesia with a reduction in the incidence and severity of side effects, which can be achieved by using lower doses of the drugs [ 25].
Magnesium may aid in maximising the effectiveness of opioids while reducing their dose, and thus the severity of side effects.
In our study, treatment of acne with two different intermittent courses was found to be effective, especially in moderate acne with a low incidence and severity of side effects.
The specificity of anticancer drugs plays an important role in reducing the severity of side effects associated with the drugs' use.
Biomarkers are useful to indicate achieved therapeutic effects or estimate risk exposure and evaluate the quality and severity of side effects.
Our present study suggests that both the single and repeated dosing regimens were similar in frequency rates and severity of side effects.
