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Hence, survival may depend on age at diagnosis, sex, disease subtype, and severity of progression of the disease.
GNAS inactivating mutations, either by presence alone or by mutation pattern within GNAS, do not predict a specific disorder, variability of phenotype, or severity of progression within this spectrum.
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For both approaches, the frequency and timing of assessments should be influenced by disease severity, speed of progression, and the questionnaire burden on patients.
Additionally, serum levels of ethanolamine plasmalogens in AD patients are decreased and correlate with the severity of disease progression (Goodenowe et al., 2007; Wood et al., 2010).
Hundreds of papers have already been published shedding light on the mechanisms of action of miRNAs, their profound stability in almost every bodily fluid and relating their presence to disease state and severity of disease progression.
This prompted us to investigate if loss of function could be involved in the length and severity of disease progression.
We observed a parallel positive relationship between the histological score of arthritis and severity of disease progression.
The total score of all 5 parameters represented the severity of OA progression in each histological section.
Moreover, the severity of phenotypic progression leading to animal death caused by lysis is inversely correlated with animal size.
Levels of EZH2 strongly associate with the severity of malignant progression and poor prognosis in breast and prostate cancer [ 17, 18].
Two adjusted cross-sectional analyses found increasing BML number and size scores were associated with increasing severity of structural progression [ 142, 143].
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