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Perhaps the limitation of current mouse models seems to reside in the lack of models that show a flare-and-wane-type of chronic disease that is most common in human SLE: all mouse models represent severe cases with increased severity of pathology over time.
In contrast to regions where the infused side was more severely affected than the contralateral side, the severity of pathology in the LSN was similar on both sides (Fig. 3f, n).
Comparison of CDS to change in the severity of pathology of individual articular elements showed statistically significant trends towards more severe pathology as CDS worsened for osteophytes (p-value for trend < 0.0001), bone marrow lesions (p = 0.0003), and subchondral sclerosis (p = 0.009), but not joint effusion or synovitis.
However, when these transgenic/knockout mice are tested using models that develop various types of age-related pathology, they show alterations in progression and/or severity of pathology as predicted by the oxidative stress theory: increased oxidative stress accelerates pathology and reduced oxidative stress retards pathology.
Patient-reported outcomes are used to assess the severity of pathology and evaluate the outcomes of both conservative and surgical treatments.
There are three suggested global indices of distress that value the level and severity of pathology: the Global Severity Index (GSI), the Positive Symptom Distress Index (PSDI), and the Positive Symptom Total (PST).
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The results for the different groups for the severity of cartilage pathology and chondrocyte pathology are graphically represented in a box plot in Figure 3.
We hypothesized that the distribution of the MR signal intensity within the nucleus zone of the intervertebral disc was modified according to the pathology and the severity of the pathology.
The dependence of the "PSM" parameter to the severity of the pathology suggests this parameter as a predictive factor of the pathology progression.
In AD the severity of NFT pathology correlates with cognitive decline, further supporting the link between tau pathology, functional impairment and neurodegeneration [ 47].
Severity of amygdala pathology was a predictive factor for memory for emotional items, and severity of hippocampal pathology predicted memory performance for neutral and emotional items (Richardson et al., 2004a).
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magnitude of pathology
severity of receptor
depth of pathology
severity of attachment
importance of pathology
severity of disorder
discipline of pathology
severity of dementia
extent of pathology
degree of pathology
severity of pathogenicity
severity of defect
severity of condition
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severity of cancer
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