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The levels of cleaved crystallin (αA-C1) appeared to be closely correlated to the severity of nuclear cataracts in γB S11R/S11R) α8(Kiα3/−) α3 lenses.
Western blotting results showed that increases of cleaved forms of αA-crystallin (αA-C1 and -C2), αB-crystallin (αB-C1 and -C2) and β-crystallin were correlated with the severity of nuclear cataracts (Figure 5B).
This result supports the observations of previous studies that other genetic modifiers play a significant role in the severity of nuclear cataracts when gap junction communication is insufficient in the lens and that the heterogeneity of nuclear cataracts was associated with the 129 and C57B6 mouse strain backgrounds [33], [34].
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The severity of these nuclear abnormalities is highly correlated with an overall accumulation of the LA∆50 protein upon passage in culture [ 63].
TOKYO — In a belated acknowledgment of the severity of Japan's nuclear disaster, the Tokyo Electric Power Company said Tuesday that three of the stricken Fukushima Daiichi plant's reactors most likely suffered fuel meltdowns in the early days of the crisis.
Disease progression occurs through a series of pre-invasive pancreatic intraepithelial neoplasia (PanIN), which are graded according to their severity of dysplasia and nuclear atypia (see Box 2) (from PanIN-1, the least severe grade, to PanIN-3, which is considered ductal carcinoma in situ and is the last grade before invasive carcinoma).
If excessive nuclear reduction contributed to severity of H1N1 influenza, therapeutic strategies targeting nuclear Trx1 may prove useful to protect individuals severely affected because of immune-mediated injury.
However, the severity of this defective mito-nuclear interaction varies across traits and genetic backgrounds, suggesting that the impact of mitochondrial dysfunction might be tissue specific.
By keeping the rest of the world in the dark about the severity of the breach of their nuclear security, those who stole the weapons are given ample time to dismantle the warheads and move them out of the country during the chaos.
Finally, we asked whether the number of nuclear actin filaments correlates with the severity of DNA damage by comparing nuclear filaments and 53BP1 foci in the same cells.
Hackers have been targeting companies that operate nuclear power stations around America, prompting the Department of Homeland Security and the FBI to issue an urgent warning about the severity of the threat, several media outlets reported on Thursday.
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