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It must be acknowledged that although all SKG + zymosan mice showed high infiltration, the severity of infiltration was highest in the SKG + zymosan + 4T1 mice.
Ng et al. (2011) reported a higher frequency of perivascular lymphocyte infiltrates in specimens from revised total knee arthroplasties than in specimens from hip arthroplasties, but with no difference in severity of infiltration.
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Severity of leukocyte infiltration was scored based on number of infiltrating cells as: (1) Mild; (2) Moderate; (3) Severe.
At different time points during AIA, rear limbs were hematoxylin and eosin stained as previously described [ 18], and the severity of joint infiltration and bone erosion was determined on a scale from 0 to 3 (0 = no infiltration, 1 = mild infiltration, 2 = moderate infiltration, 3 = maximal infiltration; 0 = no erosion, 1 = mild erosion, 2 = moderate erosion and 3 = maximal erosion).
Ordinal logistic regression examined whether bone marrow activity, lymphatic follicle activity (primary/secondary follicles, presence and degree of follicular depletion) in the spleen and pancreas of Aselli and severity of inflammatory infiltration in the liver (mild, moderate or severe) varied with age class or sex.
pDC infiltration in the lesion area has been reported in the aforementioned diseases and the severity of pDC infiltration correlates with disease progression.
pDC infiltration has been documented in multiple pathological lesions including infections, tumors, and autoimmune diseases, and the severity of pDC infiltration correlates with disease progression.
Data are presented in results section as "overall inflammation score", which represents the sum of the scores given for "inflammation", "extent and severity of leukocyte infiltration" and "percent involvement of the colon".
The severity of cellular infiltration of the TIN was similar in both groups.
However, we could not show a significant relationship between IL-21R positive cell number and the severity of lymphocytic infiltration.
An experienced pathologist evaluated all sections in a blinded fashion, and the severity of inflammatory infiltration was also assessed.
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