Owing to the severity of the indication this constitutes a unique characteristic of the study.
Motola et al 13 considered all drugs approved by the European Medicines Agency (EMA) between 1995 and 2003 according to an algorithm that considered the severity of the target indication, availability of existing treatments and size of therapeutic benefit.
Although the study is limited by the lack of randomization, the difference in duration of mechanical ventilation persisted after multivariate analysis incorporating severity of illness, mortality, indication for mechanical ventilation, use of chemical paralysis, presence of tracheostomy, and number of acquired organ system derangements.
This concept refers to the self-estimated risk that patients calculate depending on their awareness about the severity of influenza, the indications of the vaccine, the probability of contagion, and their susceptibility.
Relative risks and 95% confidence intervals adjusted for delivery year, risk factors for postpartum hemorrhage, indicators of severity of mood/anxiety disorder, other indications for antidepressants, and other drugs.
Predicting that the PDD DDD ratio depends on patient-related factors irrespective of indication or severity of the disease or sociodemographic factors like age or gender the ratio should not change with a change of the drug.
Physical rehabilitation treatments started, even if patients were mechanically ventilated, on the first day of admission, but differed individually in amount and methods due to the severity of critical illness and indication.
Conclusions: CAM is very popular in Japan and the expenditures for them are not negligible, although there is still an overwhelming dominance of orthodox Western medicine with regard to cost, variety of indications, and severity of conditions.
This association, however, was modified by the presence of fever, suspected infection and lesser illness severity and may represent the effect of indication bias.
Given the study design, we were not able to adjust for treatment indication and severity of maternal disease nor were we able to rule out confounding by indication, the underlying maternal disease, as a possible explanation for our findings.
