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Such interventions are useful in reducing the frequency and severity of challenging behaviors and the concomitant distress experienced by the individual and their carers.
Evidence was inconclusive as to the effectiveness of valproate in reducing the severity of challenging behaviour based on ABC-I scores (SMD = −0.06, CI −0.75 to 0.63, p = 0.86) and there was significant unexplained heterogeneity in findings (χ = 1.71, p = 0.19, I = 41%%).
Aripiprazole was found to be superior to placebo in terms of reducing the severity of challenging behaviour based on ABC-I scores (SMD = −0.64, CI −0.91 to −0.36, p < 0.001) and dichotomous improvement outcomes, classed as a 25%% improvement in ABC-I scores and a CGI-I rating of much improved or very much improved (RR = 0.65, CI 0.50 to 0.84, p = 0.001) (see Fig. 3).
Similar(56)
Tepco is so chastised by previous accusations of secrecy — or so overwhelmed and numbed by bad news — that it does not even try to hide the severity of challenges it is grappling with.
The lack of detail of clinical signs of pneumonia may make retrospective assessment and regrading of pneumonia severity especially challenging.
The measurement of the severity of dyspnea is challenging.
That misunderstands the severity of the challenge we're facing".
"I do not make this request lightly, but I am forced to consider every option given the severity of our challenge".
Despite the severity of the challenge, Karzai has a real opportunity to change course and get the country back on the track to progress, as it was in years following the 2002 Bonn agreement.
By the general's account, American officers have shaded the truth, understating the severity of the challenge they have met from the Iraqis at every encounter since the first American troops moved into Iraq before dawn last Thursday.
Indeed, David Axelrod and David Plouffe, the masterminds of the 2008 presidential campaign, said they cautioned Obama after his victory to brace himself for a precipitous drop in his popularity given the severity of his challenges.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com