Tepco is so chastised by previous accusations of secrecy — or so overwhelmed and numbed by bad news — that it does not even try to hide the severity of challenges it is grappling with.
Such interventions are useful in reducing the frequency and severity of challenging behaviors and the concomitant distress experienced by the individual and their carers.
Evidence was inconclusive as to the effectiveness of valproate in reducing the severity of challenging behaviour based on ABC-I scores (SMD = −0.06, CI −0.75 to 0.63, p = 0.86) and there was significant unexplained heterogeneity in findings (χ = 1.71, p = 0.19, I = 41%%).
Aripiprazole was found to be superior to placebo in terms of reducing the severity of challenging behaviour based on ABC-I scores (SMD = −0.64, CI −0.91 to −0.36, p < 0.001) and dichotomous improvement outcomes, classed as a 25%% improvement in ABC-I scores and a CGI-I rating of much improved or very much improved (RR = 0.65, CI 0.50 to 0.84, p = 0.001) (see Fig. 3).
That misunderstands the severity of the challenge we're facing".
"I do not make this request lightly, but I am forced to consider every option given the severity of our challenge".
Despite the severity of the challenge, Karzai has a real opportunity to change course and get the country back on the track to progress, as it was in years following the 2002 Bonn agreement.
By the general's account, American officers have shaded the truth, understating the severity of the challenge they have met from the Iraqis at every encounter since the first American troops moved into Iraq before dawn last Thursday.
It also underscored the severity of the challenge facing the military-led government as it struggles to restore order to the Egyptian streets without jeopardizing its own tenuous legitimacy.
A spokeswoman said: "Despite the severity of the challenge facing the council we are committed to working with the third sector and acknowledge the important role it plays in the city.
Using the epistemically normative concepts of formal epistemology as a case study, we illustrate the severity of the challenge.
