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In some cases, its severity limits patients' ability to tolerate and continue cancer therapy.
Mice were killed at pre-determined experimental end points 2, 3, 4 and 5 weeks post administration (3 mice killed/primary tumour at each experimental end point) unless pre-defined severity limits were approached or met.
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Table 1 Relation of damage category and limiting tensile strain, according to Boscardin and Cording (1989) Category of damage Degree of severity Limiting strain 0 Negligible 0−0.05 1 Very slight 0.05−0.075 2 Slight 0.075−0.15 3 Moderate 0.15−0.3 4 Severe ≥0.3.
Of the M. bovis infected cattle, animals 2735 and 2756 showed mild clinical signs of tuberculosis within the ethically acceptable severity limit, while animal 2757 developed significant clinical disease and had to be euthanazed after 6 weeks due to welfare considerations.
All non-pharmacological recommendations are identical for all levels of severity, limiting individual differentiation.
Very few studies recruited a sample that met our a priori threshold for high symptom severity, limiting our ability to draw firm conclusions.
With mostly moderate ranges of dementia the studies also represented a rather restricted range of severity limiting the scope of the analysis as the findings cannot be extrapolated to mild or severe dementia.
Several studies compared CRRT to IHD using retrospective observational designs, with inherent differences between treatment groups, such as type of dialysis membrane used and baseline illness severity, limiting the usefulness of their findings.
Animals that scored 2 for tremor, breathing or general condition, or which had lost 20% of their body weight had reached the severity limit of the experiment according to the Home Office License and were humanely culled.
The first included 23 studies indicated that disease severity, limited knowledge, comorbidities, cognitive and emotional dysfunction, communication skills, and adverse coping strategies were barriers for adequate self-management capacity.
We rated the different levels of severity (no limitations, limited a little, limited a lot) as 0, 1 and 2. We recognize that alternative weighting schemes might influence the associations between index score and outcomes of interest.
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