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No monogenic resistance to D. dadantii has been characterized but differences in symptom severity have been reported for several crops [14], [21].
Several mechanisms for increased disease severity have been proposed, including emergence of specific strains with genetic polymorphisms that encode higher levels of bacterial toxins A and B and the production of a binary toxin (3, 9, 10 ).
However, the patho-physiological significance of these cytoadherence phenotypes remains unclear as associations with severe malaria or specific signs of severity have been found in some studies [10], [20] [26] but not in others [24], [27] [29].
No reliable laboratory markers of MS severity have been found yet, but several studies investigating cytokine levels and lymphocyte subsets from the peripheral blood of MS patients [ 11, 12] have shed some light on the balance between tissue damage and repair and on the different recruitment of the various components of the immune system according to the disease stage and phenotype.
Similar findings with respect to severity have been reported with 10% of AEs classified as severe in one study of harm in a paediatric intensive care unit.
In some cases, the infractions, which have varied in severity, have been settled with the payment of a fine.
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Influence of gender on various aspects of disease severity has been described in several studies.
High expected pain severity has been found to predict severe pain [ 11, 12].
It should be noted that secondary peritonitis encompasses several different diseases and, as such, its severity has been known vary significantly [ 2].
This downturn's severity has been unusually fierce, and this spring it cut deeply into Arrow's profitability.
Over all, the pandemic's severity has been "moderate" compared with past influenza pandemics, the World Health Organization says, although it has spread with "unprecedented speed" to at least 168 countries.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com