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Our findings of increased infant mortality among SGA infants are consistent with another African study (Kasirye-Bainda and Musoke, 1992), with the risk increasing with severity of growth restriction, such that severely SGA infants had a 3-fold significantly increased hazard of death before and after adjusting for other confounders.
Kramer et al. (1989) showed that disproportionality increased with increasing severity of growth restriction, suggesting the presence of a continuum of fetal growth restriction, rather than two distinct patterns.
Although absolute head size (in centimeters) decreased with greater severity of growth restriction, head size relative to body weight increased, suggesting that brain growth might be supported while possibly restricting other organs.
10 Several studies have demonstrated that both behavioural and neurological deficits correlate with severity of growth restriction.
We sought to evaluate the impact of severity of growth restriction on mortality and major neonatal morbidity among very-low-birthweight small-for-gestational-age infants.
37 The extent of astrogliosis was correlated with the severity of growth restriction.
The mild severity of growth failure among full-term versus preterm stillbirths had already been described [ 31].
Differences in subject age, sample size, type of fitness test used and severity of growth retardation in the cohort may explain these contradictory reports.
The SGA children were divided into two subgroups based on the severity of growth restriction: children with birth weight between the 3rd and 10th percentiles (n = 11) and children with birth weight <3rd percentile (n = 14).
Figure 1 shows examples of plasmid-containing strains identified by robotic screening that showed a range of severity of growth phenotypes in the presence of the YCp- ACT1 plasmid.
The perinatal outcome of IUGR fetuses is largely dependent on the severity of growth restriction with those below the 3rd centile and/ or abnormal umbilical artery Doppler measurements at greatest risk of adverse outcome [ 1].
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