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Indeed, the same -174G allele was associated with higher disease severity evaluated with the DAS28, and an allele-dose association of the IL-6 -174G variant with increasing radiographic damage was observed in both ACPA-positive and RF-positive RA patients [ 46].
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The results have demonstrated a significant association between PASS and disease activity or severity evaluated with different indexes [ 34, 35].
Plot-scale burn severity was evaluated with the composite burn index (CBI) in locations where prefire vegetation data were available, and landscape-scale burn severity was estimated via remotely sensed indices (differenced normalized burn ratio [dNBR] and relative differenced normalized burn ratio [RdNBR]).
Stroke severity was evaluated with the National Institute of Health Stroke Scale (NIHSS) and Stroke levity scale (SLS).
Dementia severity was evaluated with the Mini-Mental State Examination (MMSE) [ 22].
Disease severity was evaluated with the clinical arthritis score, incidence of arthritis, pathological score [ 29] and radiological score.
Depression severity was evaluated with the Hamilton Depression Rating Scale (HAMD, 24 items) [ 15], and anxiety was evaluated with the Hamilton Anxiety Scale (HAMA) [ 16].
We assessed characteristics of the eating disorder illness in the AN-R sample with the Eating Disorder Inventory-2 (EDI-2) [ 24] and Body Mass Index (BMI), and depression severity was evaluated with the Beck Depression Inventory (BDI) [ 25].
Overall severity was evaluated with the Acute Physiology And Chronic Health Evaluation II (APACHE II) score [ 21] and with the Sequential Organ Failure Assessment (SOFA) score [ 22] at admission of the ICU.
ED psychopathology was assessed by means of the Eating Disorder Inventory-2 (EDI-2) [ 25] and the Binge Eating Scale (BES) [ 26] and depression severity was evaluated with the Beck Depression Inventory (BDI) [ 27].
MDD was diagnosed via the Structured Clinical Interview for DSM-IV Axis I disorders (SCID) [ 36] and global depression severity was evaluated with the clinician-administered 17-item Hamilton Rating Scale for Depression (HRSD) [ 37].
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