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While we have previously evaluated and utilized this score in rat models of sepsis [5, 41], this is the first description of its use in a murine model, where mortality and serum biochemical markers of organ failure correlated with clinical severity (data not shown).
Similar findings have been seen in multiple independent atheromas of varying severity (data not shown).
In double-receptor knockout mice (Ccr2RFP/RFPCx3cr1GFP/GFP), neurological signs of EAE were indistinguishable from those of CCR2-deficient Ccr2RFP/RFPCx3cr1+/GFP mice, indicating that CCR2 plays a dominant role in EAE severity (data not shown).
Administration of Rac1 peptide had no influence on clinical disease severity (data not shown).
There was no relationship between ASM proliferation and asthma severity (data not shown).
No associations were seen between the response to these questions and measures of diabetes severity (data not shown).
Similar(44)
Strong short-acting (33.7%) and long-acting (22.8%) opioids were the most common opioids prescribed, and use of both classes showed a significant difference across pain severity levels (P<0.0001 and P=0.0004, respectively), with greater use seen at higher pain severity levels (data not shown).
No significant differences in haplotype distribution were observed for other severity variables (data not shown).
No significant differences for TLR9 +2848 genotype distribution were observed between the groups classified by the other severity variables (data not shown).
No significant differences in TLR9 -1237 genotype distribution were observed between the groups classified by the other severity variables (data not shown).
Receiver operating characteristics curves indicated that a cut-off of 61 U/ml of anti-CCP, rather than 21 U/ml, would yield an improved positive LR of 2.01 for the severity outcome (data not shown).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com