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Trauma patients were younger, and had a higher male predominance, and less comorbidities and lower illness severity compared to the general AHRF patient population.
The lungs of animals that received CR6261 at 4 hours post challenge showed less pulmonary lesions (alveolar oedema, bronchiolitis obliterans, congestion, emphysema, bronchioloalveolar hyperplasia and primary atypical pneumonia), or showed such lesions at a lower grade of severity, compared to the lungs of animals from the other two groups.
The majority of items forming the Positive and Negative subscales (i.e. 19 items) performed very well and discriminate better along symptom severity compared to the General Psychopathology subscale.
The DCM group showed significantly more interstitial fibrosis, less perivascular fibrosis, a higher LAR value, and no difference in fatty infiltration severity compared to the CMVD group (Figs. 1 and 2).
Follow-up scores for this group at 16 and 24 weeks show a further reduction in depression severity compared to the baseline score (CDRS score change at 16 weeks: -21.6 and at 24 weeks: -23.3).
False positive subjects in the updated model had greater illness severity compared to the true negative subjects, as measured by persistence of organ failure, length of stay, and intensive care unit free days.
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Fig. 1 shows frequency of participation in the domains of Getting on with people, Autonomy and Community recreation, reported for each of the four groups of severity compared to adolescents in the general populations within each of the nine participating regions.
Histopathological results were in accordance with the findings described above; animals that received 30 and 10 mg/kg CR6261 showed much less pulmonary lesions such as primary atypical pneumonia, subacute bronch(iol)itis, emphysema and congestion, or showed such lesions at a lower grade of severity, compared to animals from the other groups.
117 In a randomized, placebo-controlled study of 51 patients with severe AD treated with IFN-γ administered subcutaneously three times weekly for 12 weeks, both low dose (500,000 U/m) and high dose (1.5 million U/m) were associated with reduced disease severity compared to placebo, with the high-dose group showing a faster initial response.
According to the inclusion and exclusion criteria, TM had chronic pain of relatively low severity compared to patients no longer on the labour market.
Since trials of oncolytic drugs are different with respect to the disease severity compared to most trials in other therapeutic areas (which may affect publication), a stratified analysis will be conducted as well.
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