There is no single definition of a rare disease, since account may need to be taken not only of the number of patients affected by it but also its severity and the availability of existing, adequate treatments.
Based on protein ratios, biological function, utility as a marker of severity, and antibody availability, we selected four proteins for validation by Western blot analysis: Ywhaz; Gpx3; Itih4; and S100a8.
Further research is needed to explore perceptions of illness severity and the availability and quality of care from public and private providers.
The choice of modality of enhanced elimination was based on several factors, such as the hemodynamic stability of a patient on admission, or the severity of poisoning, and availability of dialysis equipment.
In addition, systems must be in place for rapid modification and communication of the criteria for referral and admission, taking into account the severity of the pandemic and availability of healthcare resources.
The selection of the disorders was made through a process of consultation with primary care providers in the study setting, using the criteria of their prevalence and presentation to the primary care service, severity, associated social stigma, and availability of effective and affordable interventions.
However, other criteria for transition from child services included a combination of age and severity of condition (18%, 7/38) and availability of a service to refer on to (8%, 3/38).
Practice pattern variation has been attributed to many factors, including patient case mix and severity of illness, availability of resources and characteristics of the individual physician themselves [ 3, 4].
In terms of length of sentence and availability of parole, severity of the underlying offense, and the impact of recidivism, Andrade's sentence implicates factors relevant in both Rummel [v. Estelle] and Solem [v. Helm].
Despite recommendations and availability, utilization of severity assessment tools has lagged behind use of other guideline elements [ 15, 16], due to difficulty in calculating scores at the bedside as well as environmental features that influence the admission decision.
