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Ordered probability models with either logit or probit function is commonly applied in crash injury severity analyses; however, its critical assumption that the slope coefficients do not vary over different alternatives except the cut-off points is usually too restrictive.
The severity analyses were undertaken in a subgroup of patients where the symptom duration was known and <24 months.
To account for variations in baseline severity, analyses were stratified by baseline diabetic retinopathy status (no diabetic retinopathy and any diabetic retinopathy).
Seventy-nine (3%) participants reported a cholera diagnosis but no watery diarrhea and were excluded from cholera and disease severity analyses.
If a strict Bonferroni correction was applied for the severity analyses, the level of significance would be set at P < 0.003; and for the combined susceptibility and severity studies, the level would be set at P < 0.002.
Although these secondary severity analyses would be of lower statistical power and require replication, we propose that any positive results would reveal those pathophysiological pathways that warrant further investigation to see whether they can be exploited as potential therapeutic targets and prognostic and/or predictive biomarkers that may ultimately guide therapeutic decisions.
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For disease severity subgroup analyses, infants were classified into mild, moderate or severe disease groups.
Severity level analyses were conducted using four levels: none, mild, moderate, and severe.
Finally, in an effort to identify cytokine, chemokine, and growth factor plasmatic levels associated with severity, statistical analyses were performed after stratification of the CHIKF patients according to severity.
Only unvaccinated rotavirus-positive children (n = 69, 72%) were used in severity score analyses because RV5 is known to attenuate rotavirus illness (6 ).
In order to assess for any effect of age on convergence with ED severity, the analyses were re-run as partial correlations controlling for age.
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