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Moreover, a high population density in an agrarian society, dependent upon agriculture for its sustenance, is likely to be a severer constraint upon human welfare than would the same density in a highly industrialized society, in which the bulk of national product is not of agricultural origin.
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That alone is a severe constraint.
Subsidence in Ripon, and many other places underlain by gypsum poses a severe constraint on the development of those areas.
For most clinical applications, the low temporal resolution of reverse pharmacogenetic methods is a much less severe constraint.
Dr Peter Davis Have a total infrastructure overhaul: Inadequacies in energy, roads and seaports have been a severe constraint to development over the last 50 years.
Parliaments in Morocco, Jordan, Kuwait and Yemen offer a more pluralistic face, but even they operate under severe constraint.
The researchers project sensitivity to extreme heat will remain a severe constraint to crop production in the foreseeable future, especially as the region warms.
However, the complexity of many eukaryotic proteins places a severe constraint on successful display in Escherichia coli.
The difference in Argentina was that a lack of sufficient IMF funding at the beginning of the programme was a more severe constraint than the conditions imposed to reduce the deficit.
He is trying to undo years of corporate drift and is operating under the severe constraint of an over-stretched balance sheet and, one assumes, mighty write-downs to follow on the property portfolio.
He sang the chorus to himself — "I paid the cost to be the boss" — and remarked that one price of leadership, for Obama, had been a severe constraint on the very wanderlust that Bourdain personifies.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com