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Selenium concentrations decreased significantly with the increase of plasma HIV load among non-wasted and severely wasted adults with pulmonary tuberculosis (P = 0.0001 and P = 0.03, respectively).
15.7% children under age five in Sudan were wasted (moderate and severe) and 3.8% were classified as severely wasted, according to MICS 2000.
Total carotenoid concentrations significantly decreased with the increase of plasma HIV load among non-wasted, mildly wasted, moderately wasted and severely wasted adults (P = 0.0001, P = 0.002, P = 0.001 and P = 0.001, respectively).
The NRU receives severely wasted or oedematous patients who have no associated severe acute illness such as severe pneumonia, sepsis, or shock.
Many participants had advanced HIV disease at enrolment and were severely wasted and stunted.
Thus, there is a need to reassess risk ratios of death in children defined as severely wasted using these new growth standards instead of the former NCHS reference.
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However, the major contributors to these correlations were mice that by day 24 had lost more than 20% of their initial weight (i.e., "severely wasting" mice): these mice had high Mtb loads, severe lung pathology and low lung cell viability (Figures 1 B D, blue circles).
In severely wasting mice, these cells became especially abundant (Figure 6 F) and co-expressed low levels of F4-80, i.e., were Gr-1dimF4-80dim Gr-1dimF4-80dim Gr-1dimF4-80dim
Gr-1hi cells were present in the lungs of gaining and moderately wasting mice, but were almost absent from the lungs of severely wasting mice (Figure 6 D,E).
These results indicated that processes occurring during first 3 4 weeks of infection determined the outcome of Mtb infection and revealed that mice severely wasting on day 24 were already terminally ill.
Because terminal stage of infection may dramatically change disease manifestations (e.g., cause a secondary loss of Mtb control, as in the study of Yan and coauthors [19]), we next removed severely wasting mice from the analysis, and addressed the correlations between wasting, mycobacterial load, and lung pathology in all other mice.
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