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Glycolysis is severely perturbed in aged gastrocnemius, which shows an overabundance of several downstream glycolytic intermediates (Fig. 2).
Simulation and experimental results validate the excellent performance of the proposed method for measuring sudden step functions in electric field in presence of a severely perturbed ambient.
According to energy changing rate and power angle acceleration of the most severely perturbed generator, transient stability of power system can be detected.
It identifies the most severely perturbed generator based on relative kinetic energy of generators and electric power reflecting the change of power system.
The maximum U concentration tested in this study (1 mM) is 238 μg/g, which is higher than U concentrations recorded in most severely perturbed aquatic systems, including U mining or high-level waste release sites.
Recently it was shown that double mutants of Notch and Itch, another E3 ubiquitin ligase from the hect-family, display severely perturbed thymocyte development [44], [45].
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Treatment with 75 μM ML141 perturbed ISV formation more severely, with slightly fewer ISV sprouts and a catastrophic failure of sprouts to reach the dorsal trunk and form the DLAV, as observed in nrp1 morphants (see Figures 5E 5H).
In addition, conditional deletion of N-myc in the otic placode severely affects inner ear development, including perturbed morphology and disorganized neuronal innervation (Dominguez-Frutos et al., 2011; Kopecky et al., 2011).
This could be the consequence of decreased SCO differential expression pertaining mostly to the somatic compartment of the testis as germ cells are lacking, and meiosis being most strongly perturbed as haploid gamete formation is severely modulated by DAZ (Kee et al. 2009; Geoffroy-Siraudin et al. 2007).
In general, the cerebellar mutants, in particular the L7-∆γ2 and α6-Cacna1a mice, showed several significant impairments during locomotion adaptation that were not obvious during non-perturbed sessions (compare Tables 2 and 3).> -wrap-foot> During perturbed sessions locomotion adaptation and interlimb coordination were severely impaired in all four cerebellar mouse mutant lines.
More interestingly, we found that the most severely influenced metabolites did not always concentrate in the close neighborhood of the perturbed enzyme.
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