Sentence examples for severely inactivating from inspiring English sources

Severely inactivating mutations result in a more severe phenotype than mildly inactivating ones.

The only predicting information that genetic analysis can give regards the difference between severely inactivating (such as premature stop codon from insertion or deletion) and mildly inactivating mutations (such as missense mutations).

Severely inactivating mutations seem to give a more severe phenotype than mildly inactivating mutations.

Even in our study, although clinical symptoms are different, patients showing more severe features had a severely inactivating mutation (9).

Patients homozygous for a missense mutation seem to have a better prognosis than patients carrying a severely inactivating mutation.

However, the tagged HSV-1 viruses were severely inactivated by oxidative hydroxyl free radicals when crude HSV-1 supernatant was applied on an immobilized cobalt column and eluted by a low pH buffer.

Taken together, these studies suggest that a typical healthy individual has about 80 of their genes severely damaged or inactivated in both copies, further emphasizing the stark contrast between damage to gene and protein on the one hand, and damage to health on the other.

Moreover, inactivating the methyltransferase activity of MLL3 severely impairs cyclic methylation at the promoters of core clock genes [ 111].

Moreover, free ARG Ι was severely attenuated and nearly inactivated when the temperature rose from 40 to 70 °C.

The one remaining catalytic group that has been mutated, His to Gln, Lys, or Arg, which inactivates or severely disables the enzyme (24, 39), is explained by the fact that His is required to hold the carboxylate group of Asp in the correct place and ionization state.

Inactivating the virus can be a faster process.