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The combined results indicate that concomitant absence of BC1 RNA and FMRP results in severely heightened susceptibility to hyperexcitability and epileptogenesis, in comparison with animal models that lack only one type of translational repressor.
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Recent transfusion management of severely injured military personnel has heightened expectations for the role of blood component therapy in improving patient outcomes [ 4, 5], but evidence supporting the application of these changes to civilian healthcare has not been established and marked variation in practice exists.
Those links were severely strained after Sept. 11, as heightened border surveillance delayed traffic for as long as 12 hours.
Although infection control measures were welcomed and understood, they severely compromised quality of life and heightened the degree of complexity of work tasks that were previously fairly straightforward.
The plight of populations in the post-dzud period which lasts from late February to early spring is also a period of concern with food supplies having been exhausted and the animal supply severely depleted, and the risk of disease heightened.
Last week the Electric Reliability Council of Texas reported that the cross-state rule could curtail the operations of some coal plants so severely that it could lead to rolling blackouts — an issue that carries heightened visibility as Texas comes off a scorching summer that badly stretched power supplies.
However, a persistently heightened immune response such as that observed in chronic inflammatory disorders severely impairs host organ function, ultimately resulting in disease [1].
The refugee crisis has put key EU institutions under strain; it has heightened the danger of Brexit (which Moscow would welcome); and it has severely weakened Angela Merkel, the architect of European sanctions against Russia.
Other signs of the disorder that are evident during the first few weeks of life include: poor feeding, irregular respiration, heightened muscular tension, and rigid arching of the back; the nervous system is also severely impaired.
Your emotions are surely heightened.
The Americans heightened the pressure.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com