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In a mixed sample of autologous and allogeneic HSCT survivors in which non-fatigued and severely fatigued survivors were compared, HSCT survivors with severe fatigue reported significantly more sleep disturbance on single-item measures of sleep quality or insomnia [ 55].
The most common reasons for exclusion were: having a co-morbidity that could cause fatigue, and being severely fatigued for several years.
Patients were excluded when having a co-morbidity that could cause fatigue, or when patients indicated to be severely fatigued for several years or have been seeking treatment for their fatigue.
In a longitudinal design, we examined ex vivo DEX sensitivity of monocytes and of T-cell mitogen-induced responses of severely fatigued (N=65) and non-fatigued girls (N=60).
In addition, differences were tested on several medical variables between severely fatigued cancer patients and non-severely fatigued cancer patients.
Fifty seven severely fatigued and 21 non-fatigued cancer survivors will be recruited from the Radboud University Nijmegen Medical Centre.
A total number of 57 severely fatigued and 21 non-fatigued cancer survivors will be included (see power calculation).
Groups of severely fatigued (N = 67) and non-fatigued (N = 61) participants were selected.
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Differences on demographic and medical characteristics between severely and non-severely fatigued cancer patients were tested with χ.
Looking at our results on the subscale sleep/rest of the SIP more closely revealed four differences between severely and non-severely fatigued cancer patients.
No differences were found between severely and non-severely fatigued cancer patients on demographic variables such as sex, age, education or marital status, although the difference between males and females nearly reached significance.
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