Sentence examples for severely exhausted from inspiring English sources

T-cell exhaustion may be related with defective memory T cells formation, and the final stage of T-cell exhaustion is the physical deletion, by which severely exhausted T cells are cleared in TME.

Tim-3 and PD-1 co-expression on T cells characterizes the most severely exhausted CD8+ T-cell subset, and combined blockade of Tim-3 and PD-1 restores the function of exhausted CD8+ T cells.

One-third to half of CD8+ tumor-infiltrating lymphocytes (TILs) co-expressed PD-1 and CTLA-4, PD-1+CTLA-4+CD8+TILs were more severely exhausted in proliferation and cytokine production, whereas dual blockade of PD-1 and CTLA-4 enhanced T-cell function in cancer.

Upon arrival, he was exhausted, severely dehydrated and in physical and psychological shock that impaired his ability to speak.

The Jamaica Defence Force Coast Guard rescued the crew members the following day and brought them to Kingston Public Hospital as they were severely dehydrated and exhausted.

The baby, her firstborn, had colic, and she herself was exhausted and severely anemic.

On the return journey, in appalling Barrier weather, all the dogs perished, as Joyce had predicted, and the party returned to Hut Point on 24 March exhausted and severely frostbitten.

However, parents of severely autistic children who have exhausted all other options have described medical cannabis as a "life changing" therapy.

The Roman Empire was also severely affected, with its financial reserves exhausted by the war and the Balkans now largely in the hands of the Slavs.

Furthermore these patients have often their metabolic and neurohormonal reserves exhausted, while their immune response might be severely affected [ 7].

All of these factors have exhausted the coping mechanisms of the most vulnerable households, while severely undermining their hopes of a more secure future.