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Hypertonic stress is severely destructive for several proteins, including those of the contractile cell machinery, by causing their aggregation and misfolding in treated tissues and organs [ 41].
104 Azathioprine, ciclosporin A or cyclophosphamide RA can run a course that is refractory to several DMARDs and biological agents and can be severely destructive and disabling.
In other works, such as "The Bluest Eye," the consequences of the color fetish are the theme: its severely destructive force.
Fire, in the aftermath of an earthquake has evolved as a severely destructive force since the last century [1].
In the huC screen, there were four DUB genes whose morphants had severely destructive neuronal patterning.
28, 29 In our hands, these immunized marmosets developed acute EAE with severely destructive pathology.
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However, in patients with chronic periodontitis, mean PD and CAL values in the slightly (PSL), moderately (PM), and severely (PSE) destructive sites were progressively increased and to a significantly greater degree than those of non-destructive sites (p < 0.05) (Table 1).
In an increasingly immunocompromised population, complicated CL is becoming a more likely outcome, characterized by severely inflamed, destructive lesions that are often refractory to current treatment.
Classical mucosal lesions occurring during ATL are highly destructive, severely disfiguring, and potentially deadly.
Since infections have tendencies to be chronic, they are destructive to severely infected children, giving rise to anemia, growth retardation, impaired cognitive function, productivity of individuals, and lowered educational accomplishment (Cooper & Bundy, 1988; Guyatt, 2000; Nokes et al., 1992).
> Fungal disease is one of the major destructive diseases severely affecting the output and quality of crop.
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