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Compared to interaction in solution, anchoring of proteins into the membrane severely changes the energetic landscapes of protein protein interaction.
However, for shallow indents (nanoindetation data), the slope of the line severely changes, decreasing by a factor of ten, resulting in a "bilinear behavior".
The results obtained from the performance degradation analysis of the fractal model appears more severe than the result of the periodic models, due to the fact that the fractal model contains more roughness information, which severely changes the transmission path of the electromagnetic wave.
As for the CV curves in KOH electrolyte, although there is no obvious redox peaks, RGOA also exhibits pseudocapacitance besides electric double-layer capacitance at the potential window of −1.0 ~ −0.3 V because the current density severely changes as the potential varies within this potential window [21].
These results suggest that the A-to-I editing at position 7 of the seed of hsa-miR-6503-3p severely changes the complementarities between this miRNA and its targets, and changes the function of hsa-miR-6503-3p.
The strategy proposed in this work could not be generalized and adapted for other enzymatic systems in which the enzyme proteins do not have well-exposed N- and C-termini, or the introduction of tags severely changes the conformation and activity of the protein.
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Many paintings by Van Gogh and his contemporaries have severely changed color since they were made [1 7].
It is not always clear to us what Rembrandt's intentions were, since many of his late pictures have severely changed in appearance over time, as a result of paint alterations and old restorations.
When a high speed train enters into a tunnel, the aerodynamic forces severely change and, consequently, the stability and performance significantly deviate from the value of design point which is usually set at cruising speed on the plain ground.
But now that he needs to pander to the Tea Party, he's severely changed his tune.
You'd be best off not just playing a gig if you have to severely change what you're doing.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com