The resultant strain, MTBVAC erp−, was tested in severe combined immunodeficiency (SCID) mouse model showing to be severely attenuated when compared to BCG and MTBVAC.
Whether severely attenuated or slyly voluptuous, it has its own style -- a combination of understated bravado, brinksmanship and delicacy that amounts to a slackerish cosmopolitanism.
Indeed, non-motile mutants exerted less fluid accumulation in rabbit ileal loops62 and were severely attenuated for the colonization of infant mouse small intestines4.
A strain lacking the major flagellin subunit FlaA was severely attenuated for colonization in competition assays with wild-type bacteria in an infant mouse infection model8,9,10.
A new study by researchers from the University of California, Berkeley, and Berkeley-based Aduro BioTech provides clues why killed and severely attenuated vaccines don‰Ûªt always work.
In mutant cells, chromatin accessibility of periodic genes, including TORC1-responsive genes, is relatively static, concomitant with severely attenuated gene expression.
Above about 1020 eV cosmic rays from extragalactic sources are expected to be severely attenuated by pion photoproduction interactions with photons of the cosmic microwave background.
However, the strategic advantages of late bidding are severely attenuated in auctions that apply an automatic extension rule such as auctions conducted on Amazon.
Summary: experimental data shows that small and modest vagal bradycardia is accompanied by hyperpolarisation of the pacemaker cell which is severely attenuated by tertiapin-Q.
However, given that single deletion of the dnaK gene severely attenuated curli production (Fig. 1a) and that DnaK rather than GroEL/ES prevented CsgA aggregation in vitro (Supplementary Fig. 13), DnaK is likely the primary chaperone in curli production.
In single-channel noise reduction systems, however, these sounds are frequently severely attenuated.
