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A subgroup of adults with moderate to severely active CD (CD activity index 220 450) for ⩾4 months who had draining fistulas at baseline.
Baseline disease activity was consistent with moderately to severely active polyarticular JIA, with a mean AJC of 10.0.
Treatment with epratuzumab 2400 mg cd was well tolerated in patients with moderately to severely active SLE, and associated with improvements in disease activity.
Clowse, M. E. et al. Efficacy and safety of epratuzumab in moderately to severely active systemic lupus erythematosus: results from two phase III randomized, double-blind, placebo-controlled trials.
This product is also used for inducing and maintaining clinical response and remission in adult patients with moderately to severely active Crohn's disease with evidence of inflammation.
Adalimumab is approved worldwide for the treatment of adult patients with moderately to severely active UC.
The baseline characteristics of the study population indicate that patients had moderately to severely active RA.
One death occurred in a patient due to severely active SLE.
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Merrill, J. T. et al. Efficacy and safety of rituximab in moderately-to-severely active systemic lupus erythematosus: the randomized, double-blind, phase II/III systemic lupus erythematosus evaluation of rituximab trial.
Chronic Biologics given subcutaneously Adalimumab†, Humira® mAb Treatment of moderate-to-severely active Crohn's disease in children.
In conclusion, the anti-IP-10 antibody, BMS-936557, is a potentially effective therapy for moderately-to-severely active UC.
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