Mutations in TCap lead to autosomal recessive girdle muscular dystrophy or LGMD type 2 and severe weakness of leg muscle [66], [67].
Cauda equina syndrome was positive in one patient and severe weakness of muscle in two patients.
Yet external validity is a severe weakness of the RCT methodology for public health decision-making.
Operation indications were; to develop spinal instability, cauda equina syndrome and severe weakness of muscle due to extradural inflammatory mass or collapse of the vertebral body [ 2, 6].
They can be difficult to detect in cases of paralytic rabies due to severe weakness of neck and accessory respiratory muscles and the diaphragm.
30 The SMA disease course includes severe weakness of the auxiliary respiratory muscles, mostly sparing the diaphragm, which remains the main respiratory muscle.
The indications for surgery are; spinal instability, cauda equina syndrome, severe weakness of muscle due to extradural inflammatory mass or progressive collapse [ 6, 7].
Affected individuals share a core phenotype of rapidly progressive axonal sensorimotor neuropathy (manifesting with sensory ataxia, severe weakness of the upper limbs and axial muscles with distinctly preserved strength of the lower limbs), hearing loss, optic atrophy and respiratory insufficiency.
Five of them underwent operation at the first week of the antibiotic therapy (two for instability -figure 3-, one for cauda equina syndrome, two for severe weakness of muscle) and these patients were all in CR group.
Possible side effects: Irritability, severe weakness of the body, fainting, hair loss, problems with nails and complexion - all due to low nutritional value.
