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Due to the high level of secretion from the bacteria and its severe virulence, lethal factor (LF) has been sought as a biomarker for detecting bacterial infection and as an effective target to neutralize toxicity.
Y. enterocolitica pspC mutant has a severe virulence defect in animal [9], [25].
Thus, deletion of purMCD in type A F. tularensis or in LVS results in severe virulence attenuation in the intradermal and intranasal murine infection models.
Finally, as a result of the combined defects in the major virulence phenotypes, this mutant exhibited a severe virulence defect measured as survival in our murine inhalational model of C. gattii infection.
Despite the severe virulence of these viruses in humans, infected bats are often asymptomatic [ 13, 17– 22].
Mutations at the LPS loci in Xoo and Xcc result in severe virulence deficiency [ 7, 8, 11, 26].
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It contained several virulence factors that are associated with severe infections caused by S. aureus, including PV-luk and seb, on MGE [32], [33].
Methicillin-resistant Staphylococcus aureus (MRSA) are clinically relevant pathogens that cause severe catheter-related nosocomial infections driven by several virulence factors.
Previous studies showed that four different type of G. barbadense were resistant to both severe-virulence strains and intermediate-virulence stains of the fungus [ 4].
In E. coli, for instance, the ability to cause severe disease in humans and animals is associated with the occurrence of several virulence factors such as shigatoxins.
These results demonstrate the prominent changes in the transcriptional profile of several virulence-associated genes, including the slo and the scpC, in the all severe invasive GAS.
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