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Some severe triggers are more prevalent in poor, urban neighborhoods, including the feces of cockroaches and dust mites, cigarette smoke, mold, diesel exhaust and the dander of animals like household pets and rodents.
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The majority of AEs were mild (n = 16; 66.7%), 6 (25.0%) were moderate in severity, and 2 AEs (8.3%) were severe (trigger finger and uterine polyp).
Here, we report that severe ionization triggers rapid degradation of BRCA1, which in turn results in the activation of apoptosis.
Prolonged or severe stress triggers additional pathways that eventually lead to cellular apoptosis.
The UPR attempts to restore homeostasis in the ER but prolonged or severe UPR triggers apoptosis in the stressed cells.
Severe trauma triggers a systemic inflammatory response that contributes to secondary complications, such as nosocomial infections, sepsis or multi-organ failure.
Low levels of p53 caused by mild stress may induce arrest and damage repair and maintain cell survival, while high p53 levels in response to severe stress triggers cell death by apoptosis.
Last month, after a severe drought triggered questions about the millions of litres a day of water being sold to bottled-water companies in the province, Kathleen Wynne, Ontario's premier, promised a government review into the practice.
Last winter, a severe drought triggered stern warnings by the Environment Agency that water rationing and hosepipe bans would soon have to be introduced – until several months of torrential rain produced widespread flooding.
In the absence of a severe liquidity trigger, it would have to be forced by vendors".
The authorities in Singapore are exploring whether to charge two Singapore-based companies in connection with severe smog triggered by forest fires in Indonesia.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com